Lung diseases kill 4 million people every year.

We’re working to fix that!

We study how the immune system identifies and responds to viruses, like the flu, and thereby determines susceptibility to bacterial infections, like pneumonia.

Our research underpins the rational design of vaccines, immunotherapies for influenza and strategies to combat ‘superbug’ infections.

We’re supported by the NIH, the Francis Family Foundation and Montana State University.

I hope you enjoy learning more about our research, meeting our team, reading our blog and exploring opportunities to get involved!

Thanks for visiting,

Agnieszka Apple, Ph.D.

We have a range of active projects in two key areas: the role of viruses in bacterial superinfections; and, vaccine development.

See Pub Med for a full list of Dr Apple’s publications relating to this work.

Q Fever

Types: vaccine development

Tags: Qfever, R21, vaccine, VLP

Viral capsid recognition

Types: superinfection

Pandemic influenza

Types: vaccine development

Tags: flu, influenza, R01, vaccine

Superinfection susceptibility

Types: superinfection

Tags: R01

• Pathophysiology of Influenza D Virus Infection in Specific-Pathogen-Free Lambs with or without Prior Mycoplasma ovipneumoniae Exposure

• Culture as Medicine for the Blackfeet Community: A pilot intervention

• Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

• Experimental infection of specific-pathogen-free domestic lambs with Mycoplasma ovipneumoniae causes asymptomatic colonization of the upper airways that is resistant to antibiotic treatment